Focused on biomedical data
We provide an online service to access a platform that integrates multi-omics, clinical analysis data, scientific literature, professional clinical and nutritional intervention guides, and information on drugs and nutraceuticals to offer scientific evidence on molecular nutrition. The objective is to solve issues of malnutrition and related pathologies, the so-called non-communicable diseases.
TECHNOLOGY
|
Science and quantum AILife sciences research cannot capture the complete picture of molecular interactions without combining complementary multidisciplinary data.
|
|
Single omics studies are used to their fullest potential when combined with complementary omics studies. Rich multi-omics data sets produced by these studies, together with clinical studies data and quantum artificial intelligence, will significantly accelerate biomedicine research and transform society towards wellbeing and prevention.
Universal Omics offers user-friendly accessibility and easy management of a large amount of information, allowing the resulting files to be used directly in publications, presentations or as diagnosis / results for the end user.
Universal Omics offers user-friendly accessibility and easy management of a large amount of information, allowing the resulting files to be used directly in publications, presentations or as diagnosis / results for the end user.
APPROACH
Cell membranes |
The sensor that drives your life
By studying the alterations in relation to cell membrane, we can identify biomarkers and therapeutic targets in non-communicable diseases, which can be addressed by precise and targeted nutraceutical drugs |
Cell membranes are the perfect sensor for the metabolic stability of cells, which make up tissues and organs, and thus the whole organism.
They are composed primarily of fatty-acid-based lipids and proteins. Membrane lipids are principally of two types, phospholipids and sterols (generally cholesterol). Phospholipids form a dynamic structure with a specific permeability rate (a structure neither too fluid nor too rigid), in which other molecules such as receptors, Na+/K+ pumps, Ca2+-dependent receptors, structural proteins, kinases, etc., are embedded in a specific three-dimensional position to allow proper signalling. The cell membrane captures external signals and triggers the activation of specific metabolic pathways that result in the cell's response to an external stimulus.
Cell membrane-targeted therapy may play a key role, in particular in resolving or mitigating dysfunctions of cardiac cells, immune response or neuronal transmission, as well as redirecting to the correct metabolic pathways in obesity and diabetes.
|
Data analysis for precision nutrition and health |
We focus on the cell membrane, its modulation, fluidity and composition to determine therapeutic targets and design nutraceuticals that may modulate cell signalling.
Designing lipid- and antioxidant-based nutraceuticals in a pathological condition-specific composition may be a very effective approach for different types of cardiac disease, as anti-tumour agents, to boost the immune system or to reinforce the neurological response. |
PROJECTS
Multitarget nutraceutical for bradicardia and atrial fibrillation
A big challenge
|
Many altered molecular mechanisms of different metabolic and regulatory pathways come into play, including mutations/variations in certain genes.
On the other hand, the critical action of cardiac function is located in the cell membranes (receptors, ion pumps, kinases, etc.) of the different cardiac cell types (which also communicate with each other) and may depend on minimal variations of ions concentrations among others of much larger molecules. Controlling this is extremely complicated, it will requiere developing multi-target drugs. |
The use of possibly several integrative platforms, is crucial as clinical trials will be complicated and expensive. This turns to be a multidisciplinary project.
"There is evidence that oxidative stress and proinflammatory signaling may be significant contributors… The prevention of structural remodeling is potentially a very interesting therapeutic approach, but the ubiquitousness of many of the mechanisms makes safe and specific targeting of atrial fibrosis a challenge.” (Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy, 2020)." |
|
|
Innovative approach
|
Another way to approach the development of a nutraceutical for atrial fibrillation (AFIB) is focusing on alleviating the effects of gene alterations, and / or dependent K+, Na+ and Ca2+ receptors, or even kinases, BMP proteins, lipoproteins, etc. thus, regulatory alterations . We look for the relationship of all the studies about oxidative stress (or oxidative processes) and pro-inflammatory signalling or inflammatory processes.
|
We are working on finding a multi-component nutraceutical to regulate and counteract altered molecular actions. This product will fall into a definition of a nutraceutical. It will be about playing with lipid components and cofactors, growth factors, kinases...
We are trying to find the relationship of all possible studies on bradycardia and AFIB with inflammation and oxidative stress. |